Our Offerings

Our services

1) Feasibility analysis:

Biological sample feasibility analysis for cryoEM involves evaluating sample purity, stability, and size to ensure suitability for imaging. Factors such as buffer, pH, and conformational heterogeneity are assessed

2) Negative Staining EM (Optional)

Enhance your research capabilities with our negative staining EM analysis service, providing rapid visualization of macromolecules and complexes for structural insights.

3) Reproducible Cryogenic Sample Preparation and Screening

We offer precise cryogenic sample preparation and screening, guaranteeing reproducibility and accuracy in cryoEM analysis for robust scientific insights. With our expertise optimize your samples with a quick and reliable workflow to drive breakthroughs in structural biology.

4) Single-Particle Analysis, Heterogeneity and 2D Classification

Unlock structural intricacies with our single-particle analysis service, delving into heterogeneity through meticulous 2D classification for comprehensive molecular insights. Harness our expertise to decipher complex biological systems with clarity and precision.

5) Initial Maps (5-7 Å)

Embark on your structural journey with our initial low-resolution maps service, providing architectural insights, guiding further investigations with the first glimpse of molecular landscapes

6) High-Throughput Data Collection

Efficient molecular discoveries with our high-throughput data collection, integrating novel methodologies for rapid and precise data acquisition.

7) Refined high-resolution 3D maps (2-3 Å or better)

Elevate structural insights with our refined high-resolution 3D maps service, achieving fine details, and illuminating molecular intricacies with unprecedented clarity and precision.

8) Interpretation and modeling

Embark on an experimental odyssey with our interpretation and modeling service, meticulously sculpting structural insights and unraveling biochemical functional insights

Our cryo-em process

1

Sample Preparation

Biomolecular samples in the nanomolar to micromolar range, with a molecular weight of at least 50-60 kDa, ensuring quality through SDS-PAGE, native blue-gel, SEC column, and light scattering; join our sample feasibility analysis meeting for tailored solutions.

2

Sample Vitrification

Ensure consistency with
thin-ice grid vitrification, meticulously evaluate conditions to ensure the best data quality and reproducibility.

3

Screening

Quick state-of-the-art optimization, meticulous grid screening, addressing air-water denaturation and preferred orientation challenges and seamless screening data collection for optimal single-particle studies

4

Data Collection and Delivery

Seamless data collection to ensure top quality, providing reliable and >4x throughput data for image processing.

5

Unbiased Classification and Reconstruction

Single-particle analysis, heterogeneity analysis and 3D reconstruction for intermediate-resolution maps, offering insights into the biomolecular architecture.

High-Resolution 3D Maps

Uncover intricate molecular details and visualize biomolercular relationships with unparalleled clarity and precision in 3D